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KMID : 0191120100250060980
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Journal of Korean Medical Science
2010 Volume.25 No. 6 p.980 ~ p.983
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Skin Aging and Photoaging Alter Fatty Acids Composition, Including 11,14,17-eicosatrienoic Acid, in the Epidermis of Human Skin
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Kim Eun-Ju
Kim Min-Kyoung
Jin Xing-Ji
Oh Jang-Hee
Kim Ji-Eun
Chung Jin-Ho
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Abstract
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We investigated the alterations of major fatty acid components in epidermis by natural aging and photoaging processes, and by acute ultraviolet (UV) irradiation in human skin. Interestingly, we found that 11,14,17-eicosatrienoic acid (ETA), which is one of the omega-3 polyunsaturated acids, was significantly increased in photoaged human epidermis in vivo and also in the acutely UV-irradiated human skin in vivo, while it was significantly decreased in intrinsically aged human epidermis. The increased ETA content in the epidermis of photoaged human skin and acute UV-irradiated human skin is associated with enhanced expression of human elongase 1 and calcium-independent phophodiesterase A2. We demonstrated that ETA inhibited matrix metalloproteinase (MMP)-1 expression after UV-irradiation, and that inhibition of ETA synthesis using EPTC and NA-TCA, which are elongase inhibitors, increased MMP-1 expression. Therefore, our results suggest that the UV increases the ETA levels, which may have a photoprotective effect in the human skin.
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KEYWORD
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Ultraviolet Rays, Fatty Acids, Nonesterified, Fatty Acids, Omega-3, 11,14,17-eicosatrienoic acid, Phospholipases A2, Calcium-Independent, Human Elongase 1
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